| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8339080 | The Journal of Steroid Biochemistry and Molecular Biology | 2013 | 8 Pages |
Abstract
⺠Oestrogen biosynthesis enzymes, such as aromatase, are regulated by epigenetics. ⺠Epigenetic status is important in progression of oestrogen dependent tumours. ⺠Oestradiol (E2) is a potent modulator of epigenetic modifying enzymes. ⺠Endocrine resistance is a process that can be attributed to epigenetic changes. ⺠HDAC inhibitors are a novel treatment against endocrine resistant breast cancers.
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Authors
Kevin C. Knower, Sarah Q. To, Colin D. Clyne,