| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8339293 | The Journal of Steroid Biochemistry and Molecular Biology | 2013 | 4 Pages |
Abstract
⸠The pro-differentiation and anti-proliferative effects of 1α,25(OH)2D in human marrow stromal cells (MSCs) required VDR. ⸠With age there are declines in osteoblast differentiation of human MSCs and in its stimulation by 25(OH)D. ⸠25(OH)D3 and PTH act synergistically to stimulate osteoblastogenesis in MSCs from elders. ⸠Histone deacetylation is required for the synergistic effect of 25(OH)D3 and PTH. ⸠Epigenetic regulation of VDR may rejuvenate osteoblastogenesis in hMSCs of elders.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Shuanhu Zhou, Shuo Geng, Julie Glowacki,