Eldecalcitol and calcitriol stimulates 'bone minimodeling,' focal bone formation without prior bone resorption, in rat trabecular bone

▸ Eldecalcitol dose-dependently suppresses bone resorption and increases bone mineral density stronger than calcitriol in OVX rats in vivo. ▸ Eldecalcitol and calcitriol reduced osteoclast surface and eroded surface at the femoral trabecular bone. ▸ Calcitriol and eldecalcitol stimulated a focal bone formation that started without prior bone resorption, a process known as bone minimodeling. ▸ Both reduction of bone resorption and stimulation of focal bone formation were more clearly observed in the eldecalcitol-treated rats compared with the calcitriol-treated rats.