Differential response to 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3) in non-small cell lung cancer cells with distinct oncogene mutations

▸ Aberrant CYP24 expression limits 1,25(OH)2D3 activity in NSCLC cells. ▸ CYP24 levels are increased in NSCLC cells and lung tumors with K-ras mutations. ▸ NSCLC cells and lung tumors with EGFR mutations have low basal CYP24 levels. ▸ K-ras and EGFR mutation-positive NSCLC cells respond differentially to 1,25(OH)2D3. ▸ EGFR mutations may identify a NSCLC subset likely to benefit from 1,25(OH)2D3.