Article ID Journal Published Year Pages File Type
8339428 The Journal of Steroid Biochemistry and Molecular Biology 2013 7 Pages PDF
Abstract
▸ Dietary vitamin D3 and calcitriol exhibit equivalent tumor inhibition in mouse models of breast cancer. ▸ At moderate, achievable doses dietary vitamin D3 does not cause hypercalcemia, demonstrating safety. ▸ Tumor CYP27B1 and local calcitriol synthesis play a major role in the anticancer activity of vitamin D3. ▸ Endocrine activity of calcitriol derived from tumor and other extra-renal sources also contribute. ▸ Avoidance of vitamin D deficiency is important for reducing breast cancer risk.
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