Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8339428 | The Journal of Steroid Biochemistry and Molecular Biology | 2013 | 7 Pages |
Abstract
⸠Dietary vitamin D3 and calcitriol exhibit equivalent tumor inhibition in mouse models of breast cancer. ⸠At moderate, achievable doses dietary vitamin D3 does not cause hypercalcemia, demonstrating safety. ⸠Tumor CYP27B1 and local calcitriol synthesis play a major role in the anticancer activity of vitamin D3. ⸠Endocrine activity of calcitriol derived from tumor and other extra-renal sources also contribute. ⸠Avoidance of vitamin D deficiency is important for reducing breast cancer risk.
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Authors
Aruna V. Krishnan, Srilatha Swami, David Feldman,