| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8339498 | The Journal of Steroid Biochemistry and Molecular Biology | 2013 | 13 Pages |
Abstract
⺠Aromatase overexpressing and Letrozole resistant T47D cell lines were generated. ⺠Antiprogestin, Proellex, suppressed growth of these cells in vitro. ⺠Proellex action is mediated by inhibiting PR-B/p300 complex formation. ⺠Proellex suppresses EGFR and PR-B expression.
Keywords
ERER5020N-Nitroso-N-methylureaaromatase geneLH-RHSERMBRCAG418dNTPTMXMNURIPAMPART-PCRGAPDHEGFREGFPBS3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromideBSAcDNADMSOHER-2/neuMTTbovine serum albumincomplementary deoxyribonucleic acidsodium dodecyl sulfate-polyacrylamide gel electrophoresisSDS-PAGEReverse transcriptaseminimal essential mediumDimethylsulfoxideBreast cancerradioimmunoprecipitation assayAntiprogestinepidermal growth factorestrogen response elementphosphate buffer salineMEMSelective estrogen receptor modulatorAromatase inhibitorAromatase inhibitorsReal time polymerase chain reactionoptical densityglyceraldehyde 3-phosphate dehydrogenaseEstrogen receptorProgesterone receptor
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Authors
Akash Gupta, Rajeshwari Mehta, Fatouma Alimirah, Xinjian Peng, Genoveva Murillo, Ronald Wiehle, Rajendra G. Mehta,