| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8339530 | The Journal of Steroid Biochemistry and Molecular Biology | 2013 | 9 Pages |
Abstract
⺠Three 2α-substituted vitamin D analogs, O2C3, O1C3, and MART-10 were compared. ⺠Only O2C3 was metabolized in human liver by CYP3A4 among three analogs. ⺠MART-10 was the most resistant to CYP24A1 hydroxylation. ⺠MART-10 showed different metabolism and biological activities than other two analogs. ⺠MART-10 could be developed as a potential candidate for cancer treatment.
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Authors
Kaori Yasuda, Shinichi Ikushiro, Masaki Kamakura, Masashi Takano, Nozomi Saito, Atsushi Kittaka, Tai C. Chen, Miho Ohta, Toshiyuki Sakaki,