| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8339541 | The Journal of Steroid Biochemistry and Molecular Biology | 2013 | 10 Pages |
Abstract
⺠CAR, PXR, and FXR were transactivated in isolated hepatocytes using known agonists. ⺠Expression of CYP2E1, CYP2C33, CYP2A19, and AKR1C1 were affected. ⺠Transactivation of FXR increased 6-OH-3MI production, which favors 3MI clearance. ⺠Transactivation of PXR increased overall AND metabolism.
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Authors
Matthew A. Gray, E. James Squires,