| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8339580 | The Journal of Steroid Biochemistry and Molecular Biology | 2012 | 11 Pages |
Abstract
⺠A single UPLC-MS/MS method was developed to quantify 21 steroid metabolites. ⺠Rooibos, aspalathin and nothofagin reduced basal H295R steroid production (P < 0.01). ⺠Rooibos reduced total steroid output (P < 0.001) in forskolin stimulated H295R cells. ⺠Rooibos decreased forskolin-stimulated glucocorticoid metabolites (P < 0.001). ⺠Human CYP11B1 catalyses the conversion of A4 to 11βOH-A4.
Keywords
CYP11B1DHEACytochrome p450 side-chain cleavage3βHSDCYP21CYP11A1CYP17A1DeoxycorticosteronePROGCYP11B2DHEA-S11-dehydrocorticosteroneP450DOCdehydroepiandrosterone11-DHC17-Hydroxypregnenolone17α-HydroxyprogesteroneDehydroepiandrosterone-sulfateAldoaldosteronealdosterone synthaseandrostenedionepregnenoloneCytochrome P450ProgesteronePREGCORTCorticosterone
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Authors
Lindie Schloms, Karl-Heinz Storbeck, Pieter Swart, Wentzel C.A. Gelderblom, Amanda C. Swart,