| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8339600 | The Journal of Steroid Biochemistry and Molecular Biology | 2012 | 11 Pages |
Abstract
⺠22(S)-hydroxycholesterol (22(S)-HC) affected liver X receptor-regulated processes differently in various human-derived cell types. ⺠22(S)-HC decreased lipogenesis in myotubes and HepG2 cells while lipogenesis increased in SGBS cells. ⺠Exposure to 22(S)-HC increased glucose uptake in myotubes. ⺠Treatment with 22(S)-HC did not negatively influence cholesterol metabolism. ⺠The ability of 22(S)-HC to reduce ectopic lipid accumulation suggests a role in treatment of type 2 diabetes.
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Authors
Nina Pettersen Hessvik, Siril Skaret Bakke, Robert Smith, Aina Westrheim Ravna, Ingebrigt Sylte, Arild Christian Rustan, G. Hege Thoresen, Eili Tranheim Kase,