| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8339613 | The Journal of Steroid Biochemistry and Molecular Biology | 2011 | 13 Pages |
Abstract
⺠Prostate development is dependent on androgen action but is modulated by estrogens. ⺠Early life estrogen exposure can permanently impact adult prostate size and function ⺠Different effects of estrogen are seen at low and high doses. ⺠Early exposure to BPA and other xenoestrogens affects adult prostate morphology, androgen receptors and disease ⺠Prostate differentiation is directed by interaction of AR- and ER- driven events.
Keywords
BPATGF-βCYP7B1NKX3.1sFRPSfrp4Wnt11UGSSERMthrombospondin 2Fgf10WntERβERαERRBMP4DHTEGFIGF-15α-DihydrotestosteroneEsr1q-PCREndocrine disruptionDESBisphenol Atransforming growth factor-βShhDiethylstilbestrolUrogenital sinussonic hedgehogepidermal growth factorfibroblast growth factor 10Estrogen actioninsulin-like growth factor 1Selective estrogen receptor modulatorQuantitative reverse transcriptase-polymerase chain reactionSecreted frizzled-related proteinbone morphogenetic protein 4Secreted frizzled-related protein 4Prostate developmentAndrogen receptor geneCalpainAndrogen ReceptorEstrogen receptorEstrogen receptor αEstrogen receptor βEstrogen related receptor
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Authors
Julia A. Taylor, Catherine A. Richter, Rachel L. Ruhlen, Frederick S. vom Saal,