| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8339706 | The Journal of Steroid Biochemistry and Molecular Biology | 2010 | 5 Pages |
Abstract
Cortisol secretion and glucocorticoid excretion rates are regularly increased in obesity and associate with indices of body size and visceral adiposity. Different mechanisms may underlie the elevated urinary excretion rates of cortisol metabolites in obesity. In the present brief overview, potential mechanisms are discussed, paying special attention to cortisol metabolism. Besides, potential confounding factors in the evaluation of urinary glucocorticoid excretion are highlighted.
Keywords
11β-HSD1UFEACTHUFFTetrahydrocortisol11β-Hydroxysteroid dehydrogenase type 211β-hydroxysteroid dehydrogenase type 1WHR11β-hsd2CRFTHFadrenocorticotropinUrine volumebody mass indexBMIhypothalamic–pituitary–adrenal axisHPAhypothalamic–pituitary–adrenalUrinary free cortisolcorticotrophin-releasing factor
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Authors
Karsten Müssig, Thomas Remer, Christiane Maser-Gluth,