Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8340182 | Methods | 2017 | 12 Pages |
Abstract
Evaluation of tumor micro-environmental conditions, such as intratumoral hypoxia, is important to predict treatment outcome and efficacy. Promising non-invasive imaging-techniques have been suggested to assess tumor hypoxia and hypoxia-associated molecular responses. However, extensive validation in EC is lacking. Hypoxia-associated markers that are independent prognostic factors could potentially provide targets for novel treatment strategies to improve treatment outcome. For personalized hypoxia-guided treatment, safe and reliable makers for tumor hypoxia are needed to select suitable patients.
Keywords
CCRT18F-FMISOARCONCA IXHREESCCHIFGLUT-1DFSPDTROSAdenocarcinomaMRIOncologySurvivaldisease-free survivaloverall survivalMagnetic resonance imagingpositron-emission tomographyPhotodynamic therapyEsophageal cancerhypoxia response elementHypoxia-inducible factorVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)SUVEsophagusMeshMedical Subject HeadingsTreatment outcomeConcurrent chemoradiotherapyHypoxiacomplete responsePETHypoxia-activated prodrugEsophageal squamous cell carcinomasCarbonic anhydraseLocal controlHApReactive oxygen species
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Authors
Jurgen Peerlings, Lien Van De Voorde, Cristina Mitea, Ruben Larue, Ala Yaromina, Sebastian Sandeleanu, Linda Spiegelberg, Ludwig Dubois, Philippe Lambin, Felix M. Mottaghy,