Constitutive DPP4 activity, inflammation, and microvascular reactivity in subjects with excess body weight and without diabetes

Article ID	Journal	Published Year	Pages	File Type
8340812	Microvascular Research	2018	31 Pages	PDF

Abstract

Constitutive DPP4 activity was associated with early markers of endothelial proinflammatory activation and microvascular function, and may have an influence and even be influenced by inflammation and microvascular blood flow in subjects with excess body weight without diabetes.

Keywords

DPP4 VCAM-1 CD26 NGT IL-6 FPG mRNA OGTT PSW ICAM-1 HOMA-IR PAI-1 GIP LDF GLP-1 AUC Oral glucose tolerance test EDTA Endothelial dysfunction homeostasis model assessment of insulin resistance ethylenediamine tetraacetic acid American Diabetes Association interleukin-6 normal glucose tolerance tumor necrosis factor-α dipeptidyl peptidase 4 dipeptidyl peptidase IV messenger ribonucleic acid Human vascular smooth muscle cells body mass index BMI TNF-α laser Doppler flowmetry Fasting plasma glucose Insulin resistance Plasminogen activator inhibitor-1 intercellular adhesion molecule-1 vascular cell adhesion molecule-1 Microvascular reactivity ADA high-sensitivity C-reactive protein glucagon-like peptide-1 Prediabetes Pre-diabetes Plasma glucose glucose-dependent insulinotropic polypeptide