Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8341208 | Microvascular Research | 2015 | 9 Pages |
Abstract
In the group of ENG mutation carriers, we detected 67 differentially expressed mRNAs, of which 62 were down-regulated in the telangiectasial tissue. Gene set analysis identified the gene ontology (GO) terms vasculogenesis, TGF-β signaling, and Wnt signaling as differentially expressed in HHT1. Altered Wnt signaling might be related to HHT pathogenesis and a greater understanding of this may lead to the discovery of therapeutic targets in HHT.
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Authors
Pernille M. Tørring, Martin Jakob Larsen, Anette D. Kjeldsen, Lilian Bomme Ousager, Qihua Tan, Klaus Brusgaard,