Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8341382 | Microvascular Research | 2013 | 9 Pages |
Abstract
All these findings demonstrate that melatonin may play a role in the paracrine interactions that take place between malignant epithelial cells and proximal endothelial cells. Melatonin could be important in reducing endothelial cell proliferation, invasion, migration and tube formation, through a downregulatory action on VEGF. Taken together, our findings suggest that melatonin could potentially be beneficial as an antiangiogenic agent in breast cancer with possible future clinical applications.
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Authors
Virginia Alvarez-GarcÃa, Alicia González, Carolina Alonso-González, Carlos MartÃnez-Campa, Samuel Cos,