Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8343060 | Molecular Genetics and Metabolism | 2018 | 42 Pages |
Abstract
The conformation of ACE is tissue-specific. In Gaucher disease, ACE produced by activated splenic macrophages differs from that in hepatic macrophages, as well as from macrophages and dendritic cells in sarcoid granulomas. The observed differences are likely due to altered ACE glycosylation or sialylation in these diseased organs. The conformational differences in ACE may serve as a specific biomarker for Gaucher disease.
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Authors
Sergei M. Danilov, Victoria E. Tikhomirova, Roman Metzger, Irina A. Naperova, Tatiana M. Bukina, Ozlem Goker-Alpan, Nahid Tayebi, Nurshat M. Gayfullin, David E. Schwartz, Larisa M. Samokhodskaya, Olga A. Kost, Ellen Sidransky,