Newborn screening for carnitine palmitoyltransferase II deficiency using (C16Â +Â C18:1)/C2: Evaluation of additional indices for adequate sensitivity and lower false-positivity

These findings suggested that CPT II deficiency can be screened by using (C16 + C18:1)/C2 and C16 as indices. An appropriate cutoff level is required to achieve adequate sensitivity albeit at the cost of a considerable increase in the false-positive rate, which might be reduced by using additional indices such as C14/C3.