Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8343742 | Molecular Genetics and Metabolism | 2015 | 8 Pages |
Abstract
Cognitive impairment, a major difficulty for many MPS I patients, is associated with genotype, age at treatment and somatic disease burden. IQ association with white matter differed from controls. Many attenuated MPS patients have significant physical and/or cognitive problems and receive insufficient support services. Results provide direction for future clinical trials and better disease management.
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Authors
Elsa G. Shapiro, Igor Nestrasil, Kyle Rudser, Kathleen Delaney, Victor Kovac, Alia Ahmed, Brianna Yund, Paul J. Orchard, Julie Eisengart, Gregory R. Niklason, Julian Raiman, Eva Mamak, Morton J. Cowan, Mara Bailey-Olson, Paul Harmatz, Suma P. Shankar,