| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8343968 | Molecular Genetics and Metabolism | 2013 | 10 Pages |
Abstract
In this paper we review the current advances in mtDNA methylation studies with particular attention to the evidences of mtDNA methylation changes in diseases and physiological conditions so far investigated. Technological advances for the analysis of epigenetic variations are promising tools to provide insights into methylation of mtDNA with similar resolution levels as those reached for nDNA. However, many aspects related to mtDNA methylation are still unclear. More studies are needed to understand whether and how changes in mtDNA methylation patterns, global and gene specific, are associated to diseases or risk factors.
Keywords
HcyTETTFAS-adenosylhomocysteineSHMTMSCC5-MTHFnDNASAMTFBCBSCThSAHMBEMTHFR5hmCTHFDnmtNAFLDMCATranscription factor B5mC5-methyl-tetrahydrofolate5-Methylcytosine5-hydroxymethylcytosinecystathionine γ-lyaseDNA methyltransferaseMitochondrial DNANuclear DNAMethylated DNA immunoprecipitationROSS-adenosylmethioninenonalcoholic steatohepatitisamyotrophic lateral sclerosisCHARMAIMSEpigeneticschromatin immunoprecipitationAlzheimer diseaseALSParkinson diseaseNonalcoholic fatty liver diseaseBiomarkertetrahydrofolatemtDNAserine hydroxymethyltransferaseDown's syndromecystathionine β-synthaseSAHHMatMethyltransferaseMethylationMethylenetetrahydrofolate reductasemethionine adenosyltransferaseMethionine synthaseNash homocysteineCHiPReactive oxygen species
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Authors
Vito Iacobazzi, Alessandra Castegna, Vittoria Infantino, Generoso Andria,