| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8344098 | Molecular Genetics and Metabolism | 2012 | 13 Pages |
Abstract
⺠Mutant Sialidase enzyme activity can be rescued by chemical chaperones and proteosomal inhibitors. ⺠Inhibition of proteosome potentiates targeting of misfolded Sialidase to the lysosome. ⺠This work identifies drugs that can treat Sialidosis, a lysosomal storage disease.
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Authors
Erin M. O'Leary, Suleiman A. Igdoura,