| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8344423 | Nitric Oxide | 2018 | 22 Pages |
Abstract
Nitro-fatty acids (NO2-FA) are pleiotropic modulators of redox signaling pathways. Their effects on inflammatory signaling have been studied in great detail in cell, animal and clinical models primarily using exogenously administered nitro-oleic acid. While we know a considerable amount regarding NO2-FA signaling, endogenous formation and metabolism is relatively unexplored. This review will cover what is currently known regarding the proposed mechanisms of NO2-FA formation, dietary modulation of endogenous NO2-FA levels, pathways of NO2-FA metabolism and the detection of NO2-FA and corresponding metabolites.
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Authors
Gregory J. Buchan, Gustavo Bonacci, Marco Fazzari, Sonia R. Salvatore, Stacy Gelhaus Wendell,