| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8346049 | Nitric Oxide | 2013 | 8 Pages |
Abstract
⺠Xanthine oxidoreductase (XOR) catalyzes NO formation from NO2- under anoxia. ⺠Inhibition of XOR diminishes beneficial outcomes mediated by NO2- treatment. ⺠However, inhibition of XOR produces salutary outcomes in similar models. ⺠The in vivo significance of XOR-derived NO formation from NO2- is thus unclear. ⺠We critically review key factors that combine to “switch” XOR from oxidant to NO production.
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Authors
Nadiezhda Cantu-Medellin, Eric E. Kelley,