| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8346093 | Nitric Oxide | 2013 | 24 Pages |
Abstract
- 5,14-HEDGE, a 20-HETE mimetic, reversed hypotension and tachycardia in endotoxemic rats.
- 5,14-HEDGE prevented LPS-induced increase in expression/activity of iNOS/sGC/PKG pathway, COX-2, and NOX2.
- LPS-induced decrease in CYP4A1 expression and 20-HETE production was prevented by 5,14-HEDGE.
- 5,14-HEDGE prevented LPS-induced increase in peroxynitrite formation.
- Stable 20-HETE mimetics may have a therapeutic value in the treatment of septic shock.
Keywords
NF-κBIκBIKKHspeNOSs.c.i.p.PKGSGCiNOSERKRT-PCRcGMPVASPCOX-2NADPHCyPTNFmRNA20-HETECYP4A1LPSCOX20-Hydroxyeicosatetraenoic acidcDNAIκB kinaseMAPKsEHcyclooxygenaseArachidonic acidepoxyeicosatrienoic acidcomplementary deoxyribonucleic acidHypotensionEndotoxininterleukinELISAEnzyme-linked immunosorbent assaySoluble guanylyl cyclaseEETIntraperitoneallymessenger ribonucleic acidsubcutaneouslyinducible nitric oxide synthaseendothelial nitric oxide synthaseHeart ratetumor necrosis factornuclear factor-κBmean arterial pressurelipopolysaccharideMEKinhibitor of κBcyclic guanosine monophosphatemapNitric oxidenicotinamide adenine dinucleotide phosphateSoluble epoxide hydrolaseVasodilator stimulated phosphoproteinreverse transcription-polymerase chain reactionHeat shock proteinmitogen-activated protein kinase kinase 1protein kinase Gmitogen-activated protein kinaseprostaglandinextracellular signal-regulated kinase
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Bahar Tunctan, Belma Korkmaz, Ayse Nihal Sari, Meltem Kacan, Demet Unsal, Mehmet Sami Serin, C. Kemal Buharalioglu, Seyhan Sahan-Firat, Tuba Cuez, Wolf-Hagen Schunck, Vijaya L. Manthati, John R. Falck, Kafait U. Malik,