Stability, toxicity and intestinal permeation enhancement of two food-derived antihypertensive tripeptides, Ile-Pro-Pro and Leu-Lys-Pro

- Food-derived tripeptides, IPP and LKP, have potential antihypertensive effects.
- In vitro studies demonstrated stability against rat intestinal and liver homogenates.
- Cytotoxicity assays found IPP and LKP to be innocuous in intestinal and liver cell lines.
- Intestinal permeability of FITC-peptides was increased in the presence of medium chain fatty acids.
- Data suggest a formulation strategy for oral IPP and LKP.