Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8347905 | Peptides | 2015 | 6 Pages |
Abstract
We conclude that the acute combined administration of the strongly insulinotropic GLP-1 and glucagon, both in vivo and in vitro, did not induce any additive or synergistic action on glucose-stimulated insulin secretion. This shows that the risk of a marked insulinotropic action when the two compounds are given together most likely does not result in increased risk of hypoglycemia.
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Authors
Giovanni Pacini, Bo Ahrén,