Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8347947 | Peptides | 2015 | 9 Pages |
Abstract
Results have showed that there is a reduced cell population increase that is peptide-, cell- and possibly pathway-specific, with the most potent effect observed in observed in T-47D breast cancer cells. Protein expression and microscopy results further indicate that, in this cell line, the peptide with the sequence GPPPQGGRPQG (GG peptide) interferes with the ability of cell adhesion proteins to stabilize adherens junctions, such as E-cadherin, leading to apoptosis. These promising results encourage future works aimed at disclosing the vast potential of salivary peptides as new therapeutic agents.
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Authors
João Pinto da Costa, Virginia Carvalhais, Francisco Amado, Artur Silva, Rita Nogueira-Ferreira, Rita Ferreira, LuÃsa Helguero, Rui Vitorino,