Aedes cadherin mediates the in vivo toxicity of the Cry11Aa toxin to Aedes aegypti

- Aedes cadherins were stably expressed in a mosquito cell line and silenced in transgenic mosquitoes.
- Cells expressing Aedes cadherin are more sensitive to Cry11Aa, Cry4Aa, and Cry11Ba toxins, but not Cry4Ba.
- Cells expressing Aedes cadherin trigger Cry11Aa oligomerization just as with lepidopteran cadherins.
- Transgenic mosquitoes with silenced Aedes cadherin show increased tolerance to Cry11Aa toxin.