| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8348061 | Peptides | 2015 | 8 Pages |
Abstract
- JZTX-II inhibits the fast inactivation of Nav1.5 with high selectivity over other VGSC subtypes.
- The binding site for JZTX-II was determined as the S3-S4 linker of Nav1.5 domain IV.
- D1609 might be the main determinant involved in the selectivity of JZTX-II on the VGSC subtypes.
Keywords
Related Topics
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Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Ying Huang, Xi Zhou, Cheng Tang, Yunxiao Zhang, Huai Tao, Ping Chen, Zhonghua Liu,