Functional characterization of five different PRXamide receptors of the red flour beetle Tribolium castaneum with peptidomimetics and identification of agonists and antagonists

- 70 different analogs of PRXamide peptide were tested on five different receptors.
- A ligand acting on multiple receptors is common.
- Agonistic or antagonistic peptidomimetics on CAPA receptor are first described.
- TcPKr-A is more promiscuous to agonists, while TcPK-C is more so to antagonists.