| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8348152 | Peptides | 2015 | 12 Pages |
Abstract
- Significantly higher BBB permeability for linear vs. cyclic enkephalin analogs.
- Nanomolar μ-opioid receptor affinity for the four enkephalin analogs.
- Significanlty higher antinociception for NMe- vs. S-enkephalin analogs.
Keywords
LNAAAllocDAPNMMHBTURP-HPLCLC-MSTriisopropylsilanePTSTFAMTRFMOCBOCtBuFluorenylmethyloxycarbonylNMPCYCSDIEADCMTISDMFN-methylmorpholine[d-Pen2,d-Pen5]-enkephalinDPDPEMPEN-MethylpyrrolidoneHEPESMOR2-(1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate4-(2-Hydroxyethyl)piperazine-1-ethanesulfonic acidAUCBSADMSODAMGOMEIδ-Opioid receptorμ-Opioid receptorbovine serum albuminallyloxycarbonylTrifluoroacetic acidLarge neutral amino acidsMaximum possible effectDADLEDORCNSdiisopropylethylaminedimethylformamideDichloromethaneDimethylsulfoxideBlood–brain barrierBBBcentral nervous systemAntinociceptive activitySEMarea under the curvePolystyrenereversed-phase high-performance liquid chromatographyhigh-performance liquid chromatographyHPLCMethyl iodide
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Authors
Mathieu Verbeken, Evelien Wynendaele, Elodie Mauchauffée, Nathalie Bracke, Sofie Stalmans, Engin Bojnik, Sandor Benyhe, Kathelijne Peremans, Ingeborgh Polis, Christian Burvenich, Albert Gjedde, Jean-François Hernandez, Bart De Spiegeleer,