Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8348280 | Peptides | 2014 | 5 Pages |
Abstract
Biphalin, a mixed MOP/DOP agonist, displays a potent antinociceptive activity in numerous animal models of pain. The aim of the study was to characterize the anti-inflammatory and antinociceptive action of biphalin in the mouse models of colitis. The anti-inflammatory effect of biphalin (5 mg/kg, twice daily, i.c. and i.p.) was characterized in a semi-chronic mouse model of colitis, induced by i.c. injection of trinitrobenzenesulfonic acid (TNBS). The antinociceptive action of biphalin (5 mg/kg, i.p. and i.c.) in inflamed mice was assessed in mustard oil-induced model of visceral pain and in the hot plate test. In the semi-chronic mouse model of colitis, biphalin i.c. (5 mg/kg), but not i.p. improved colitis macroscopic score (2.88 ± 0.19 and 4.99 ± 0.80 units for biphalin and vehicle treated animals, respectively). Biphalin injected i.p. and i.c. (5 mg/kg) displayed a potent antinociceptive action in the mustard oil-induced pain test. In the hot plate test, biphalin (5 mg/kg, i.p.) produced a potent antinociceptive activity in inflamed mice, suggesting central site of action. Our data suggest that biphalin may become a novel opioid-based analgesic agent in IBD therapy and warrant further investigation of its pharmacological profile.
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Authors
Marta Sobczak, Andrzej Pilarczyk, Mateusz Jonakowski, Agata Jarmuż, Maciej SaÅaga, Andrzej W. Lipkowski, Jakub Fichna,