Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8348565 | Peptides | 2013 | 9 Pages |
Abstract
Brain natriuretic peptide (NT-pro-BNP) was implicated in the regulation of hypothalamic-pituitary-adrenocortical (HPA) responses to psychological stressors. However, HPA axis activation in different physical stress models and its interface with NT-pro-BNP in the prediction of cardiopulmonary performance is unclear. Cardiopulmonary test on a treadmill was used to assess cardiopulmonary parameters in 16 elite male wrestlers (W), 21 water polo player (WP) and 20 sedentary age-matched subjects (C). Plasma levels of NT-pro-BNP, cortisol and adrenocorticotropic hormone (ACTH) were measured using immunoassay sandwich technique, radioimmunoassay and radioimmunometric techniques, respectively, 10 min before test (1), at beginning (2), at maximal effort (3), at 3rd min of recovery (4). In all groups, NT-pro-BNP decreased between 1 and 2; increased from 2 to 3; and remained unchanged until 4. ACTH increased from 1 to 4, whereas cortisol increased from 1 to 3 and stayed elevated at 4. In all groups together, ÎNT-pro-BNP2/1 predicted peak oxygen consumption (B = 37.40, r = 0.38, p = 0.007); cortisol at 3 predicted heart rate increase between 2 and 3 (r = â0.38,B = â0.06, p = 0.005); cortisol at 2 predicted peak carbon-dioxide output (B = 2.27, r = 0.35, p < 0.001); ÎACTH3/2 predicted peak ventilatory equivalent for carbon-dioxide (B = 0.03, r = 0.33, p = 0.003). The relation of cortisol at 1 with NT-pro-BNP at 1 and 3 was demonstrated using logistic function in all the participants together (for 1/cortisol at 1 B = 63.40, 58.52; r = 0.41, 0.34; p = 0.003, 0.013, respectively). ÎNT-pro-BNP2/1 linearly correlated with ÎACTH4/3 in WP and W (r = â0.45, â0.48; p = 0.04, 0.04, respectively). These results demonstrate for the first time that HPA axis and NT-pro-BNP interface in physical stress probably contribute to integrative regulation of cardiopulmonary performance.
Keywords
ACTHSBPDBPCPETFFMBSANt-pro-BNPCardiopulmonary testCardiopulmonary exercise testfat massFat Free Massbody surface areaHeart ratediastolic arterial blood pressuresystolic arterial blood pressureStress axisHypothalamic–pituitary–adrenocortical axisPeak oxygen consumptionHPAadrenocorticotropic hormonehypothalamic–pituitary–adrenocorticalbody weightbrain natriuretic peptidecontrolscortisol
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Authors
Dejana Popovic, Bojana Popovic, Bosiljka Plecas-Solarovic, Vesna PeÅ¡iÄ, Vidan Markovic, Stanimir Stojiljkovic, Vladan Vukcevic, Ivana Petrovic, Marko Banovic, Milan Petrovic, Bosiljka Vujisic-Tesic, Miodrag C. Ostojic, Arsen Ristic,