Article ID Journal Published Year Pages File Type
8348710 Peptides 2013 5 Pages PDF
Abstract
► Diabetes induced hyperglycemia and reduced Na+K+ ATPase in rat sciatic nerve. ► MDA was elevated whereas BAP, GSH and SOD were decreased. ► BKB1 antagonist R-954 restored neuronal activity and reduced oxidative stress. ► BKB1-R is expressed in sciatic nerve as evidenced by inhibitory effects of R-954. ► The beneficial role of R-954 for diabetic neuropathy is suggested.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
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Bradykinin B1 antagonism inhibits oxidative stress and restores Na+K+ ATPase activity in diabetic rat peripheral nervous system
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