Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8348853 | Peptides | 2013 | 6 Pages |
Abstract
⺠The Ghr acted to promote NO release and had an inhibitory effect on hypoxia-induced HPAECs apoptosis. ⺠Ghr-mediated protective effect was accompanied by the phosphorylation of Akt and eNOS. ⺠The PI3 K/Akt pathway plays a key role in hypoxia-induced dysfunction in HPAECs. ⺠The Ghr demonstrates a significant potential to prevent and treat PAH.
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Authors
Dan Yang, Zhihong Liu, Hongliang Zhang, Qin Luo,