Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8348904 | Peptides | 2013 | 10 Pages |
Abstract
⺠EXf is a novel peptide analog of Exendin-4 with two amino acid substitutions. ⺠EXf improved glycemic control and β-cell function, restored islet morphology. ⺠EXf stimulated proliferation and inhibited apoptosis of β-cells. ⺠EXf improved islet β-cell survival by PI3 K/Akt1 signal pathway. ⺠EXf may slow down the diabetes progress in diabetic KKAy mice.
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Authors
Guo-jiang Hou, Cai-na Li, Shuai-nan Liu, Yi Huan, Quan Liu, Su-juan Sun, Lin-yi Li, Shao-cong Hou, Zhu-fang Shen,