| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8348906 | Peptides | 2013 | 8 Pages |
Abstract
⺠Bradykinin attenuated basal and LPS-induced NO production in BV2 microglial cells. ⺠A protein kinase A inhibitor mimicked the effects of Bradykinin, while cAMP elevating agents antagonized Bradykinin-mediated NO decrease. ⺠Moreover, Bradykinin inhibited the activation of cAMP responsive element binding protein expression. ⺠Bradykinin protected microglial cells from death triggered by a combination of LPS and each of the cAMP elevating agents. ⺠Gαi protein inhibitor abrogated the effects of BK on NO release, and the expression of Gαi protein in the plasma membrane was induced by BK.
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Authors
Sarit Ben-Shmuel, Abraham Danon, Sigal Fleisher-Berkovich,