Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8350051 | Pharmacology Biochemistry and Behavior | 2018 | 20 Pages |
Abstract
The doses of NLX-112 which induce hypothermia or corticosterone release were similar to those inducing serotonergic behaviors but greater than those reported previously in models of therapeutic-like activity (range 0.04 to 0.16Â mg/kg). Overall, the present study provides information for clinical dose estimations of NLX-112 and suggests that therapeutic effects may occur at doses below those at which biomarker responses are observed.
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Authors
Newman-Tancredi A., Depoortère R., Carilla-Durand E., Tarayre J.P., Kleven M., Koek W., Bardin L., Varney M.A.,