| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8351143 | Pharmacology Biochemistry and Behavior | 2014 | 7 Pages |
Abstract
Tramadol reversed the changes in mechanical sensitivity as well as anxiety-related and depression-associated behaviors that are caused by injury of the sciatic nerve with only minor effects in the absence of injury. These data suggest that tramadol relieves chronic pain and its indirect consequences and comorbidities, and that this study also is a model for pharmacological studies seeking to investigate the effect of drugs on the major disabling symptoms of NP.
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Authors
Ombretta Caspani, Marie-Céline Reitz, Angelo Ceci, Andreas Kremer, Rolf-Detlef Treede,