Abnormal involuntary movement (AIM) expression following D2 dopamine agonist challenge is determined by the nature of prior dopamine receptor stimulation (priming) in 6-hydroxydopamine lesioned rats

Article ID	Journal	Published Year	Pages	File Type
8352065	Pharmacology Biochemistry and Behavior	2013	8 Pages	PDF

Abstract

âº Priming with D1, D2 or D1/D2 agonists in 6-OHDA rats leads to sensitization of AIMs. âº Treatment of 6-OHDA rats with D2 agonist leads to primarily axial and locomotor AIMs. âº D1 stimulation in 6-OHDA rats leads to larger repertoire of AIMs than D2 stimulation. âº D2 challenge in 6-OHDA rats leads to AIMs that mirror the responses during priming.

Keywords

MPTP SKF SKF38393 QUIN 6-OHDA i.p.6-Hydroxydopamine 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine l-3,4-dihydroxyphenylalanine l-DOPA apo Apomorphine AIMS Parkinson's disease tyrosine hydroxylase abnormal involuntary movements Behavioral sensitization intraperitoneal Quinpirole