The ruthenium NO donor, [Ru(bpy)2(NO)SO3](PF6), inhibits inflammatory pain: Involvement of TRPV1 and cGMP/PKG/ATP-sensitive potassium channel signaling pathway

Article ID	Journal	Published Year	Pages	File Type
8352137	Pharmacology Biochemistry and Behavior	2013	9 Pages	PDF

Abstract

âº [Ru(bpy)2(NO)SO3](PF6) (complex I) reduced overt pain-like behavior. âº Complex I reduced carrageenin-induced hyperalgesia and myeloperoxidase activity. âº Complex I diminished capsaicin (TRPV1 agonist)-induced nociception. âº Complex I effect depends on cGMP/PKG/ATP-sensitive potassium channel signaling.

Keywords

CFA phenyl-p-benzoquinone KT5823 HTAB guanylate cyclase ODQ PBQ PKG TRPV1 channel eNOS PGE2 ALT iNOS NSAIDS TRPV1 cGMP NOS 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one complete Freund's adjuvant MPO AST Aspartate aminotransferase Alanine aminotransferase Nitric oxide donor Nonsteroidal anti-inflammatory drugs endothelial nitric oxide synthase myeloperoxidase Nitric oxide nitric oxide synthase Hexadecyltrimethylammonium bromide Transient receptor potential vanilloid 1 Hyperalgesia protein kinase G cGMP-dependent protein kinase Prostaglandin E2 TRP channels Transient receptor potential channels Capsaicin Gly Glybenclamide

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry

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The ruthenium NO donor, [Ru(bpy)2(NO)SO3](PF6), inhibits inflammatory pain: Involvement of TRPV1 and cGMP/PKG/ATP-sensitive potassium channel signaling pathway

Authors

Larissa Staurengo-Ferrari, Sandra S. Mizokami, Jean J. Silva, Francisco O.N. da Silva, Eduardo H.S. Sousa, Luiz G. da França, Mariana L. Matuoka, Sandra R. Georgetti, Marcela M. Baracat, Rubia Casagrande, Wander R. Pavanelli, Waldiceu A. Jr.,