| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8352236 | Pharmacology Biochemistry and Behavior | 2013 | 10 Pages |
Abstract
⺠Brain adenosine modulation on Pavlovian learning is investigated in two mutant models. ⺠Up- and down-regulation of cortical adenosine severely impaired conditioned freezing. ⺠The conditioned freezing impairment does not generalize to other Pavlovian paradigms. ⺠Adenosine homeostasis is critically important for maintaining normal brain function. ⺠Regional specific effects are relevant for development of adenosine-based therapies.
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Authors
Philipp Singer, Chuchu Zhang, Detlev Boison, Benjamin K. Yee,