| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8352271 | Pharmacology Biochemistry and Behavior | 2013 | 10 Pages |
Abstract
⺠Piperine is an alkaloid and bioactive constituent of plants from the Piper genus. ⺠It is a potent anticonvulsant drug against pilocarpine-induced convulsions in mice. ⺠Its effects are not altered in the presence of memantine or nimodipine. ⺠Its effects are potentiated by diazepam and blocked by flumazenil. ⺠Its activity involves GABAergic mechanisms and TNF-alpha decreases.
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Authors
Giovany Michely Pinto da Cruz, CÃcero Francisco Bezerra Felipe, Fúlvio Alexandre Scorza, Marta Aline Coelho da Costa, Alinne Farias Tavares, Maria Luiza Feitosa Menezes, Geanne Matos de Andrade, Luzia Kalyne A.M. Leal, Gerly Anne C. Brito,