Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8359044 | Prostaglandins & Other Lipid Mediators | 2018 | 19 Pages |
Abstract
Eicosatrienoic acids (EETs) are a class of intermediates produced during arachidonic acid metabolism mediated by cytochrome P450 epoxygenases that exert multiple physiological effects on the nervous system. EETs promote three metabolic processes, including esterification, hydrolysis and degradation or extension. EETs are hydrolyzed by soluble epoxide hydrolase (sEH) to form corresponding diols, thereby reducing their biological activity. Strategies regulating sEH expression or activity affect EET hydrolysis and alter relative cell concentrations, thus influencing EET function. This article summarizes the metabolic pathway of eicosatrienoic acid in organisms and highlights its neuroprotective effects on the central nervous system, which include regulating neuronal excitability, increasing cerebral blood flow, inhibiting neuronal apoptosis, reducing neuroinflammation, mitigating brain injury and promoting recovery of neurological function in subjects with nervous system diseases.
Keywords
MCAO/RPPAR-γTBIAUDAEETsCREBJnkTrkBIL-1βERKc-Jun N-terminal protein kinaseDHETNMDA receptorOGD/RsEHadenylate cyclaseTraumatic brain injuryAktArachidonic acidepoxyeicosatrienoic acidsdihydroxyeicosatrienoic acidMiddle cerebral artery occlusion and reperfusionInterleukin-1βtropomyosin receptor kinase BNervous systemNeuroprotectionSoluble epoxide hydrolasecAMP response element-binding proteinprotein kinase BExtracellular signal–regulated kinasesPeroxisome proliferator-activated receptor gamma
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Authors
Lai Wang, Gan Luo, Long-Fei Zhang, Hui-Xia Geng,