Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8359054 | Prostaglandins & Other Lipid Mediators | 2018 | 24 Pages |
Abstract
Although oxylipins are involved in inflammation, data on these lipid mediators in multiple sclerosis are sparse. In this study, a panel of oxylipins were analysed swith liquid chromatography tandem mass spectrometry in cerebrospinal fluid (CSF) from 41 treatment naïve patients with clinically isolated syndrome (CIS) or relapsing remitting MS (RRMS) and 22 healthy controls. CSF levels of 9-hydroxyoctadecadienoic acid (9-HODE) and 13-hydroxyoctadecadienoic acid (13-HODE) were significantly higher in patients than in healthy controls (9-HODE median 380ânM (interquartile range 330-450ânM) in patients and 290ânM (interquartile range 250-340ânM) in controls, 13-HODE median 930ânM (interquartile range 810-1080ânM) in patients and 690ânM (interquartile range 570-760ânM) in controls, pâ<â0.001 in Mann-Whitney U tests). 9-HODE and 13-HODE performed well for separation of patients and healthy controls (AUC 0.85 and 0.88, respectively, in ROC curve analysis). However, baseline CSF levels of the oxylipins did not differ between patients with signs of disease activity during one, two and four years of follow-up and patients without. In conclusion, this study indicates that 9-HODE and 13-HODE levels are increased in CSF from CIS and RRMS patients compared with healthy controls, but does not support 9-HODE or 13-HODE as prognostic biomarkers of disease activity in patients during follow-up.
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Authors
Irene HÃ¥kansson, Sandra Gouveia-Figueira, Jan Ernerudh, Magnus Vrethem, Nazdar Ghafouri, Bijar Ghafouri, Malin Nording,