Atrial natriuretic peptide suppresses Th17 development through regulation of cGMP-dependent protein kinase and PI3K-Akt signaling pathways

Article ID	Journal	Published Year	Pages	File Type
8361206	Regulatory Peptides	2013	8 Pages	PDF

Abstract

âº Naïve CD4+ T cells also could express natriuretic peptide receptor A(NPRA). âº ANP signaling could suppress the development of Th17 cell. âº NPRA/cGMP/PKG is the major pathway for ANP's inhibitory effect on Th17 cell. âº PI3K-Akt signaling was implicated in ANP-induced suppression to Th17 development.

Keywords

PI3K ROR ANP PKG BATF retinoid-related orphan receptor STAT Th17 cells phosphatidylinositol 3′-kinase Signal transducer and activator of transcription Npra Atrial Natriuretic Peptide (ANP)cGMP-dependent protein kinase atrial natriuretic peptide Natriuretic Peptide Receptor A

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry

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Atrial natriuretic peptide suppresses Th17 development through regulation of cGMP-dependent protein kinase and PI3K-Akt signaling pathways

Authors

Libing Ma, Jinxiu Li, Guyi Wang, Subo Gong, Li Zhang, Keng Li, Xiaoying Ji, Yi Liu, Ping Chen, Xudong Xiang,