| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8361211 | Regulatory Peptides | 2013 | 5 Pages |
Abstract
⺠Exendin-4, unlike native GLP-1 is cleared solely via the kidneys. ⺠Renal clearance of GLP-1 exceeds the glomerular filtration rate. ⺠Exendin-4 differs from GLP-1 by having a COOH-terminal extension. ⺠We investigated the importance of this extension in anaesthetized pigs. ⺠Addition of the extension of exendin-4 to GLP-1 reduced its metabolic clearance.
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Authors
L. Simonsen, J.J. Holst, K. Madsen, C.F. Deacon,