| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8361279 | Regulatory Peptides | 2012 | 6 Pages |
Abstract
⺠Estrogen-deficient state promotes increased pro-inflammatory cytokines and impairment of the natriuretic peptide system. ⺠Increased IL-6 and TNF-α, in addition to decreased ANP levels, contributes to increased cardiovascular disease. ⺠We demonstrated that tibolone reduces serum TNF-α levels and increases plasma ANP levels. ⺠The anti-inflammatory effects of tibolone may prevent cardiovascular disease in the long-term.
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Authors
Ana Raquel Santos de Medeiros, Aline Zandonadi Lamas, Izabela Facco Caliman, Polyana L. Meireles Dalpiaz, Luciana Barbosa Firmes, Gláucia Rodrigues de Abreu, Margareth Ribeiro Moysés, Elenice Moreira Lemos, Adelina Martha dos Reis,