Receptor-mediated inhibition of small bowel migrating complex by GLP-1 analog ROSE-010 delivered via pulmonary and systemic routes in the conscious rat

Article ID	Journal	Published Year	Pages	File Type
8361286	Regulatory Peptides	2012	6 Pages	PDF

Abstract

âº The GLP-1 peptide analog ROSE-010 delivered by the pulmonary route with Technosphere® inhalation powder inhibits gut motility. âº Inhibition of gut motility by ROSE-010 works through the GLP-1 receptor similar to natural GLP-1. âº Technosphere® inhalation powder has the potential of pharmaceutical use of peptides like GLP-1 and ROSE-010.

Keywords

IBS Gastrointestinal motility Pulmonary delivery irritable bowel syndrome Glucagon

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry

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Receptor-mediated inhibition of small bowel migrating complex by GLP-1 analog ROSE-010 delivered via pulmonary and systemic routes in the conscious rat

Authors

P.M. Hellström, A. Smithson, G. Stowell, S. Greene, E. Kenny, C. Damico, A. Leone-Bay, R. Baughman, M. Grant, P. Richardson,