Glucagon-like peptide-1 (GLP-1) receptor agonism or DPP-4 inhibition does not accelerate neoplasia in carcinogen treated mice

► GLP-1 receptor agonists and DPP-4 inhibitors are extensively used as anti-diabetic drugs. ► We investigated if GLP-RAs and a DPP-4 inhibitor had trophic effects in the mouse intestine. ► We also investigated if a GLP-RA and a DPP-4 inhibitor had tumour promoting effects in the colon of carcinogen treated mice. ► GLP-1 RAs significantly increased intestinal growth, but we found no tumour promoting effect in the colon.